Neurofilament heavy chain in secondary progressive multiple sclerosis
CSF neurofilaments are better outcomes than serum neurofilaments in small SPMS studies. CSF NfH and NfL variably predict worsening hand function, information processing speed and brain volume loss, possibly reflecting complementary aspects of neurodegeneration.
Authors
- Christopher John Weir (ORCID: https://orcid.org/0000-0002-6494-4903)
- Jeremy Chataway (ORCID: https://orcid.org/0000-0001-7286-6901)
- Sharmilee Gnanapavan (ORCID: https://orcid.org/0000-0003-2817-9922)
- Anisha Doshi (ORCID: https://orcid.org/0000-0001-6699-8668)
- Domenico Plantone (ORCID: https://orcid.org/0000-0001-6666-7244)
- Nevin John (ORCID: https://orcid.org/0000-0002-9834-4498)
- Jonathan Stutters (ORCID: https://orcid.org/0000-0002-9151-0844)
- Floriana De Angelis (ORCID: https://orcid.org/0000-0002-9833-1435)
- Francesca Ammoscato
- Klaus Schmierer (ORCID: https://orcid.org/0000-0002-9293-8893)
- Frederik Barkhof (ORCID: https://orcid.org/0000-0003-3543-3706)
- Richard Anthony Parker (ORCID: https://orcid.org/0000-0002-2658-5022)
- David MacManus (ORCID: https://orcid.org/0000-0002-0902-977X)
- Thomas Williams (ORCID: https://orcid.org/0000-0001-6920-1562)
- Gavin Giovannoni
Institutions
- University of Siena (IT)
- Queen Mary University of London (GB)
- National Institute for Health and Care Research (GB)
- Monash Health (AU)
- National Hospital for Neurology and Neurosurgery (GB)
- University College London (GB)
- Monash University (AU)
- Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
- University of Edinburgh (GB)
Publication Details
- Journal
- Multiple Sclerosis Journal
- Published
- 2025-01-22
- DOI
- https://doi.org/10.1177/13524585241311212
- Citations
- 3
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 4.41