Bridging thrombolysis with tenecteplase versus endovascular thrombectomy alone for large-vessel anterior circulation stroke: a target trial emulation analysis
Tenecteplase before thrombectomy compared with thrombectomy alone did not increase the probability of functional independence but resulted in significant improvement over the full mRS scale. This improvement was most evident in patients treated early.
Authors
- Urs Fischer (ORCID: https://orcid.org/0000-0003-0521-4051)
- Vignan Yogendrakumar (ORCID: https://orcid.org/0000-0001-8814-6853)
- Valerian Altersberger (ORCID: https://orcid.org/0000-0002-0610-9328)
- Leonid P. Churilov (ORCID: https://orcid.org/0000-0002-9807-6606)
- Jan Gralla (ORCID: https://orcid.org/0000-0003-1953-9033)
- Johannes Kaesmacher (ORCID: https://orcid.org/0000-0002-9177-2289)
- Timothy John Kleinig (ORCID: https://orcid.org/0000-0003-4430-3276)
- Daniel Strbian (ORCID: https://orcid.org/0000-0001-9095-2344)
- Peter Mitchell (ORCID: https://orcid.org/0000-0002-8337-7529)
- Bruce C.V. Campbell (ORCID: https://orcid.org/0000-0003-3632-9433)
- David Seiffge (ORCID: https://orcid.org/0000-0003-3890-3849)
Institutions
- University of Bern (CH)
- Royal Adelaide Hospital (AU)
- The Royal Melbourne Hospital (AU)
- University of Helsinki (FI)
- University of Ottawa (CA)
- The University of Melbourne (AU)
- University of Basel (CH)
- Helsinki University Hospital (FI)
- Ottawa Hospital (CA)
- University Hospital of Bern (CH)
- University Hospital of Basel (CH)
Publication Details
- Journal
- Journal of Neurology Neurosurgery & Psychiatry
- Published
- 2025-01-22
- DOI
- https://doi.org/10.1136/jnnp-2024-335325
- Citations
- 4
- Primary Topic
- Acute Ischemic Stroke Management
- Type
- article
- Field-Weighted Citation Impact
- 5.42
Funders
- Australian Government
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Medical Research Council
- National Health and Medical Research Council