Association of mineral metabolism biomarkers in patients with chronic kidney disease and renal transplant recipients: A single-centre prospective study

Holistic assessment of mineral bone disorder parameters, including serum calcium, phosphorus, parathyroid hormone, and 1,25-dihydroxyvitamin D, can predict renal outcomes in kidney transplant recipients, though results have varied. This study aimed to evaluate the biochemical parameters of mineral bone disorder in patients with chronic kidney disease and renal transplant recipients. A total of 78 patients with chronic kidney disease, 24 post-renal transplant recipients, and 28 control cases were included, with a mean age of 48.24 years. The predominant cause of chronic kidney disease was chronic glomerulonephritis, followed by diabetes and hypertension. Serum levels of calcium, phosphorus, parathormone, and vitamin D3 were assessed. Patients with chronic kidney disease exhibited a mean serum calcium level of 8.37 mg/dL and phosphorus level of 4.25 mg/dL, while post-transplant patients had mean levels of 8.17 and 4.15 mg/dL, respectively. A significant reduction in serum parathyroid hormone levels was observed post-transplant (mean 8.13 U/dL) compared to patients with chronic kidney disease (mean 24.39 U/dL). No significant changes were noted in vitamin D3 levels after transplantation. Regression analysis revealed an insignificant relationship between serum calcium and phosphorus levels and parathyroid hormone levels. This study highlights the biochemical imbalances associated with chronic kidney disease and the impact of renal transplantation on parathyroid hormone levels, emphasising the need for regular monitoring and management of mineral bone disorder parameters in these patient populations