Usage of tranexamic acid in patient with thrombocyte hypoaggregability as a prevention of perioperative bleeding in patient undergoing dentoalveolar surgery.

Thrombocyte hypoaggregation (hypoaggregability), deserves а special attention regarding bleeding tendency during perioperative dentoalveolar surgery. The diagnosis primary is based on history data of prolonged bleeding and reduced levels of ADP, collagen, and ristocetin, as predictive indicators, directly indicative for high risk of postextraction bleeding (PEB). Usage of tranexamic acid (TXA) in prophylaxis and therapy of (PEB) is a gold standard managing these patients. The aim of this study was to establish the protocol for diagnosing the hypoagreggability and to determine the effectiveness and safety of TXA in managing PEB. Materials and Methods: 64 patients with hypoaggregability were treated at the University Clinic for Maxillofacial Surgery in Skopje,2019- 2024 year. Diagnosis was based on finding of reduction levels for ADP, ristocetin and collagen. Determinate doses of TXA were applicated, side effects were noted and clinical data of location extraction were correlated with the PEB. Results: 88.2% of the patients are diagnosed due to persistent gingival bleeding in the oral cavity and significant indicators for diagnosing hypoaggregabulity were ADP, ristocetin and collagen in 100% of cases. 2/64 patients have side effect of i.v. application of TXA, presented with nausea and vomiting. There were no events of bleeding in 99% of patient using TXA preoperatively.