Method for Testing Drugs Belonging to Substrates and Inhibitors of the Transporter Protein BCRP on CACO-2 Cells
A method of testing drugs for affiliation to BCRP substrates and inhibitors using methotrexate (5 μM) and mitoxantrone (10 μM) as marker substrates and reserpine (50 μM) as inhibitor was developed and tested on Caco-2 cells.
Authors
- P. Yu. Mylnikov (ORCID: https://orcid.org/0000-0001-7829-2494)
- A. V. Shchulkin (ORCID: https://orcid.org/0000-0003-1688-0017)
- И. В. Черных (ORCID: https://orcid.org/0000-0002-5618-7607)
- A. A. Slepnev (ORCID: https://orcid.org/0000-0003-0696-6554)
- Yu. S. Tranova (ORCID: https://orcid.org/0000-0001-5068-1201)
- E. N. Yakusheva (ORCID: https://orcid.org/0000-0001-6887-4888)
- N. M. Popova (ORCID: https://orcid.org/0000-0002-5166-8372)
- M. I. Povetko (ORCID: https://orcid.org/0000-0003-1273-520X)
Institutions
- Ryazan State Medical University named after Academician I.P. Pavlov (RU)
Publication Details
- Journal
- Doklady Biochemistry and Biophysics
- Published
- 2025-01-22
- DOI
- https://doi.org/10.1134/s1607672924701266
- Citations
- 1
- Primary Topic
- Drug Transport and Resistance Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.05