Advanced Distance-Resolved Evaluation of the Perienhancing Tumor Areas with FLAIR Hyperintensity Indicates Different ADC Profiles by <i>MGMT</i> Promoter Methylation Status in Glioblastoma
Distance-resolved volumetric ADC analysis around the tumor core reveals tissue signatures of GBM imperceptible to the human eye on conventional MRI. The different ADC profiles around the core suggest epigenetically influenced differences in perienhancing tissue characteristics between mMGMT and uMGMT GBM.
Authors
- Michael Weller (ORCID: https://orcid.org/0000-0002-1748-174X)
- Gergely Bertalan (ORCID: https://orcid.org/0009-0000-3986-9844)
- Zsolt Kulcsár (ORCID: https://orcid.org/0000-0002-6805-5150)
- Tibor Hortobágyi (ORCID: https://orcid.org/0000-0001-5732-7942)
- Andrea Bink (ORCID: https://orcid.org/0000-0002-2163-3400)
- Nicolin Hainc (ORCID: https://orcid.org/0000-0003-0916-7387)
- Émilie Le Rhun (ORCID: https://orcid.org/0000-0002-9408-3278)
- Fabian Dominik Von Dehn
Institutions
- University Hospital of Zurich (CH)
Publication Details
- Journal
- American Journal of Neuroradiology
- Published
- 2025-01-23
- DOI
- https://doi.org/10.3174/ajnr.a8493
- Citations
- 1
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.63