Translation of laser speckle contrast imaging for blood flow monitoring
We explore the potential of laser speckle contrast imaging (LSCI) for intraoperative cerebral blood flow (CBF) monitoring during neurosurgery. Unlike current intraoperative tools that offer intermittent insights, LSCI can provide continuous, real-time visualization of blood flow and tissue perfusion. We report on results from a dual-center prospective observational study of patients undergoing neurovascular surgery for which a microscope-integrated LSCI device tracked CBF throughout procedures such as aneurysm clipping and bypass surgery. Results showed that LSCI effectively captured rapid changes in blood vessel flow and cortical tissue perfusion, suggesting LSCI can address current limitations in CBF monitoring during critical moments in surgery.
Authors
- Johannes Goldberg (ORCID: https://orcid.org/0000-0002-6066-3549)
- Andreas Raabe (ORCID: https://orcid.org/0000-0002-3886-466X)
- David R. Miller (ORCID: https://orcid.org/0000-0002-8091-1861)
- Alexis Dimanche (ORCID: https://orcid.org/0000-0002-6445-3709)
- Michael Murek (ORCID: https://orcid.org/0000-0002-9874-1135)
- Colin T. Sullender (ORCID: https://orcid.org/0000-0003-4329-7708)
- Andrew K. Dunn (ORCID: https://orcid.org/0000-0001-6500-5783)
- David Bervini (ORCID: https://orcid.org/0000-0003-4873-4452)
- Benjamin K Hendricks (ORCID: https://orcid.org/0000-0002-7123-4387)
- Michael T. Lawton
Institutions
- University Hospital of Bern (CH)
- St. Joseph's Hospital (US)
- The University of Texas at Austin (US)
- University of Oklahoma (US)
Publication Details
- Published
- 2025-01-23
- DOI
- https://doi.org/10.1117/12.3054971
- Primary Topic
- Thermoregulation and physiological responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00