TIGIT expression on natural killer cell subsets is an early indicator of alleviating liver inflammation following bulevirtide treatment in chronic hepatitis D
We here suggest that lacking the expression of the immune checkpoint inhibitor TIGIT on NK cell subtypes may be a hallmark of liver inflammation in HDV infection. BLV therapy is associated with a reappearance of TIGIT on these cells, which may be one mechanism of why liver enzymes rapidly improve during therapy.
Authors
- Birgit Bremer (ORCID: https://orcid.org/0000-0002-1239-6968)
- Niklas K. Björkström (ORCID: https://orcid.org/0000-0002-0967-076X)
- Albert Heim (ORCID: https://orcid.org/0000-0002-9447-1561)
- Helenie Kefalakes (ORCID: https://orcid.org/0000-0002-1120-4506)
- Sophie Anna Engelskircher (ORCID: https://orcid.org/0009-0008-5947-6069)
- Qingyu Wu (ORCID: https://orcid.org/0000-0003-0561-9315)
- Lisa Sandmann (ORCID: https://orcid.org/0000-0003-4425-2640)
- Heiner H. Wedemeyer (ORCID: https://orcid.org/0000-0003-2906-0480)
- Norman Woller (ORCID: https://orcid.org/0000-0002-4928-0117)
- Anke Kraft (ORCID: https://orcid.org/0000-0002-9666-0753)
- Katja Deterding
- Kerstin Port (ORCID: https://orcid.org/0000-0001-8338-3227)
- Tijana Ristic (ORCID: https://orcid.org/0009-0000-9061-8469)
- Markus Cornberg
- Po-Chun Chen (ORCID: https://orcid.org/0009-0002-7578-5482)
- Athira Chakkadath
Institutions
- Karolinska University Hospital (SE)
- Karolinska Institutet (SE)
- Medizinische Hochschule Hannover (DE)
- German Center for Infection Research (DE)
- Helmholtz Centre for Infection Research (DE)
- Centre for Individualised Infection Medicine (DE)
Publication Details
- Journal
- Hepatology
- Published
- 2025-01-23
- DOI
- https://doi.org/10.1097/hep.0000000000001238
- Citations
- 3
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 2.39
Funders
- Falk Foundation
- Eli Lilly and Company
- Pfizer
- Gilead Sciences
- Deutsches Zentrum für Infektionsforschung
- European Commission
- Deutsche Forschungsgemeinschaft
- Swedish Orphan Biovitrum