Choice of Drug for Malaria Prevention During Pregnancy Does Not Affect Infant Serologic Responses to <i>Plasmodium falciparum</i> Erythrocyte Membrane Proteins 1
While sulfadoxine-pyrimethamine has been the primary drug in intermittent preventive treatment in pregnancy, dihydroartemisinin-piperaquine (DP) is being considered as an alternative. DP may lead to lower antimalarial antibodies in the mother, resulting in higher risk of malaria in infancy. We probed cord blood sera collected from women enrolled in a clinical trial of sulfadoxine-pyrimethamine vs DP on a protein microarray containing diverse <i>Plasmodium falciparum</i> erythrocyte membrane proteins 1 to measure the impact of intermittent preventive treatment in pregnancy on proteins associated with malaria disease susceptibility. These results suggest that effective maternal malaria prevention may not alter the susceptibility of infants to malaria.
Authors
- Omid Taghavian
- Philip L. Felgner (ORCID: https://orcid.org/0000-0002-4117-8505)
- Don P. Mathanga (ORCID: https://orcid.org/0000-0001-6816-1888)
- Mark A. Travassos (ORCID: https://orcid.org/0000-0002-6045-3322)
- Miriam K. Laufer (ORCID: https://orcid.org/0000-0001-8300-9593)
- Jobiba Chinkhumba (ORCID: https://orcid.org/0000-0002-1921-619X)
- Ankur Sharma (ORCID: https://orcid.org/0000-0002-6862-136X)
- Matthew Adams (ORCID: https://orcid.org/0000-0001-7062-903X)
- L Andronescu (ORCID: https://orcid.org/0000-0003-3342-7820)
- Algis Jasinskas
- Aarti Jain (ORCID: https://orcid.org/0000-0002-9536-0097)
- Rie Nakajima (ORCID: https://orcid.org/0000-0002-6026-3342)
- Amed Ouattara (ORCID: https://orcid.org/0000-0003-1964-7130)
Institutions
- University of Maryland, Baltimore (US)
- University of California, Irvine (US)
- Kamuzu Central Hospital (MW)
- Kamuzu University of Health Sciences (MW)
Publication Details
- Journal
- Open Forum Infectious Diseases
- Published
- 2025-01-23
- DOI
- https://doi.org/10.1093/ofid/ofaf037
- Primary Topic
- Malaria Research and Control
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health