Nutrient control of splice site selection contributes to methionine addiction of cancer
Our results link nutritional demands to splicing changes and thereby provide a link between the cancer-specific metabolic phenomenon, described as methionine addiction over 40 years ago, with a defined cellular pathway that contributes to cancer cell proliferation.
Authors
- Klemens J. Hertel (ORCID: https://orcid.org/0000-0002-7560-9529)
- Francisco Carranza (ORCID: https://orcid.org/0000-0003-1789-4197)
- Stacey L. Borrego
- Linda Lauinger (ORCID: https://orcid.org/0000-0003-2543-8562)
- Anna Andronicos (ORCID: https://orcid.org/0000-0002-4351-9166)
- Harika Reddy Pulipelli
- Peter Kaiser
- Dawei Lin (ORCID: https://orcid.org/0000-0002-8171-9898)
- Lucas D de Paula
Institutions
- University of California, Irvine (US)
Publication Details
- Journal
- Molecular Metabolism
- Published
- 2025-01-23
- DOI
- https://doi.org/10.1016/j.molmet.2025.102103
- Citations
- 3
- Primary Topic
- Amino Acid Enzymes and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 3.34
Funders
- National Institutes of Health
- National Cancer Institute
- National Institute of General Medical Sciences