Astragaloside IV ameliorates autism-like behaviors in BTBR mice by modulating Camk2n2-dependent OXPHOS and neurotransmission in the mPFC
The evidence demonstrates that ASIV may become a promising treatment option for ASD and implies that targeting the Camk2n2/Camk2/CREB axis is warranted to investigate these ASD individuals further.
Authors
- Xiaotang Fan (ORCID: https://orcid.org/0000-0001-5694-1828)
- Yi Luo
- Tianyao Liu (ORCID: https://orcid.org/0000-0002-7646-5969)
- Jiahui Shi
- Hong Gong (ORCID: https://orcid.org/0000-0003-4393-1078)
- Xin Li (ORCID: https://orcid.org/0000-0002-7121-7069)
- Jianghui Li
- Yulong Liu (ORCID: https://orcid.org/0000-0001-5212-6076)
- Jing Luo (ORCID: https://orcid.org/0000-0003-0751-8681)
- Mei Chen (ORCID: https://orcid.org/0000-0003-4613-2626)
- Jiayin Liu (ORCID: https://orcid.org/0000-0001-7554-9661)
Institutions
- Army Medical University (CN)
- Southwest Hospital (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-01-23
- DOI
- https://doi.org/10.1016/j.jare.2025.01.030
- Citations
- 7
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 4.05
Funders
- National Natural Science Foundation of China
- Key Technologies Research and Development Program