Perception of COVID-19 Vaccination and Uptake Willingness in Northern Nigeria: Understanding Strategies to Optimize Coverage

<b>Background:</b> Vaccination is a proven and safe method for combating COVID-19; however, coverage remains low in many low- and middle-income countries, including Nigeria. There is also a lack of contextual evidence regarding the public perception of and willingness to receive vaccines. This study aims to contribute to efforts to optimize the vaccination coverage and improve public health in northern Nigeria. <b>Objective:</b> This study investigated the perceptions of COVID-19 vaccination and willingness to uptake the vaccine in northern Nigeria, aiming to identify strategies for optimizing coverage and enhancing vaccination rates. <b>Methods:</b> A cross-sectional household survey was conducted across the Federal Capital Territory and five northern states in Nigeria. The survey assessed the respondents' perceptions of COVID-19, their knowledge of the COVID-19 vaccine, and their willingness to be vaccinated. Descriptive and inferential (multivariate logistic regression) statistical analyses were employed to characterize the population and identify predictors of vaccine uptake. <b>Results:</b> The mean age of the respondents was 28.00 years. The majority reported at least one piece of misinformation regarding COVID-19. While awareness of the vaccine was high, its actual uptake was low, and future willingness to receive the vaccine was also limited. Employment status emerged as a significant predictor of vaccine uptake, as determined through the multivariate analysis. Furthermore, collaboration with NGOs and community-based organizations (CBOs) was identified as the most effective strategy for enhancing vaccine uptake. <b>Conclusions:</b> This study found a concerningly low willingness to receive the COVID-19 vaccine among participants in northern Nigeria. To address this issue, we recommend establishing partnerships with NGOs and CBOs, implementing extensive public awareness campaigns, and conducting community outreach programs. These efforts should focus on dispelling misinformation, building community trust, and promoting vaccine uptake through culturally appropriate communication materials.