Short, extended and continuous infusion of β-lactams: predicted impact on target attainment and risk for toxicity in an ICU patient cohort
In a Swedish ICU cohort target attainment rates for primary pathogens were high regardless of infusion strategy. In WCS pathogens, SI was insufficient, suggesting the benefit of routine use of EI or CI. However, for cefotaxime, target attainment remained low also with EI and CI. The use of CI might lead to unnecessarily high concentrations, but well-established toxicity levels are lacking and future studies are warranted.
Authors
- Siv Jönsson (ORCID: https://orcid.org/0000-0001-8240-0865)
- Christian G. Giske (ORCID: https://orcid.org/0000-0003-4327-6122)
- Maria Swartling (ORCID: https://orcid.org/0000-0001-8816-0567)
- Anna-Karin Smekal
- Miklós Lipcsey (ORCID: https://orcid.org/0000-0002-1976-4129)
- Elisabet I. Nielsen (ORCID: https://orcid.org/0000-0003-0725-214X)
- Mia Furebring (ORCID: https://orcid.org/0000-0001-6142-7890)
Institutions
- Uppsala University (SE)
- Karolinska University Hospital (SE)
- Karolinska Institutet (SE)
Publication Details
- Journal
- Journal of Antimicrobial Chemotherapy
- Published
- 2025-01-23
- DOI
- https://doi.org/10.1093/jac/dkaf013
- Citations
- 2
- Primary Topic
- Antibiotics Pharmacokinetics and Efficacy
- Type
- article
- Field-Weighted Citation Impact
- 2.79
Funders
- Akademiska Sjukhuset
- Uppsala Universitet