Adjuvant Chemotherapy After Resection of Localized Pancreatic Adenocarcinoma Following Preoperative FOLFIRINOX
In this cohort study, adjuvant (m)FOLFIRINOX and other multiagent chemotherapy regimens were associated with improved OS following resection of localized pancreatic adenocarcinoma after preoperative (m)FOLFIRINOX, whereas single-agent adjuvant chemotherapy was not. The impact of adjuvant chemotherapy on OS may be lower in subgroups such as patients with 8 or more preoperative cycles of (m)FOLFIRINOX, those having radiological response, and those with ypN0.
Authors
- Thilo Hackert (ORCID: https://orcid.org/0000-0002-7012-1196)
- Roeland F. de Wilde (ORCID: https://orcid.org/0009-0003-0444-8697)
- Tobias Keck (ORCID: https://orcid.org/0000-0001-7651-6183)
- Raphaël Bourdariat
- Giedrius Barauskas (ORCID: https://orcid.org/0000-0002-4321-7280)
- Ajay N. Jain (ORCID: https://orcid.org/0000-0003-4641-8501)
- Keiichi Akahoshi (ORCID: https://orcid.org/0000-0003-3792-5659)
- Jeanne Dembinski
- Marc G. Besselink (ORCID: https://orcid.org/0000-0003-2650-9350)
- Lilian Schwartz
- Damiano D. Caputo (ORCID: https://orcid.org/0000-0001-7058-1945)
- Kürşat Dikmen (ORCID: https://orcid.org/0000-0002-9150-9499)
- Yuta Ushida (ORCID: https://orcid.org/0000-0003-3076-8013)
- Johan Gagnière (ORCID: https://orcid.org/0000-0002-1820-3362)
- Keith Roberts (ORCID: https://orcid.org/0000-0003-1799-9829)
- Motokazu Sugimoto (ORCID: https://orcid.org/0000-0002-1654-0613)
- Julien Taı̈eb (ORCID: https://orcid.org/0000-0002-9955-4753)
- Giuseppe Malleo (ORCID: https://orcid.org/0000-0001-5467-2628)
- Poya Ghorbani (ORCID: https://orcid.org/0000-0003-2102-7168)
- Bas Groot Koerkamp (ORCID: https://orcid.org/0000-0003-1917-6973)
- Morgan Bonds
- Paul Suno Krohn
- Asif Halimi
- Jörg Kleeff (ORCID: https://orcid.org/0000-0003-3432-6669)
- Hanneke W.M. van Laarhoven (ORCID: https://orcid.org/0000-0003-1274-5643)
- Mahsoem Ali (ORCID: https://orcid.org/0000-0002-0511-6323)
- Knut Jørgen Labori (ORCID: https://orcid.org/0000-0001-6777-7955)
- Zohra V. Aslami
- Gianpaolo Balzano (ORCID: https://orcid.org/0000-0003-4636-4566)
- Tomohisa Yamamoto (ORCID: https://orcid.org/0000-0002-7951-7429)
- Giuseppe Fusai (ORCID: https://orcid.org/0000-0002-8784-6919)
- Stefan Kobbelgaard Burgdorf (ORCID: https://orcid.org/0000-0003-2844-2129)
- Safi Dokmak (ORCID: https://orcid.org/0000-0002-7811-2155)
- Braden N. Miller
- Adnan Alseidi (ORCID: https://orcid.org/0000-0002-0365-1955)
- Ulla Klaiber (ORCID: https://orcid.org/0000-0002-9287-1174)
- Alejandro Serrablo (ORCID: https://orcid.org/0000-0002-9762-3612)
- Attila Bursics
- Olivier R. Busch (ORCID: https://orcid.org/0000-0001-9605-6831)
- Richard A. Burkhart (ORCID: https://orcid.org/0000-0003-1087-0870)
- Stijn van Roessel (ORCID: https://orcid.org/0000-0002-3041-0452)
- Ronald M. van Dam (ORCID: https://orcid.org/0000-0001-8415-5090)
- Rupaly Pandé (ORCID: https://orcid.org/0000-0003-2346-373X)
- Daisuke Hashimoto (ORCID: https://orcid.org/0000-0002-7880-889X)
- Thomas F. Stoop (ORCID: https://orcid.org/0000-0003-3328-4516)
- Lysiane Marthey (ORCID: https://orcid.org/0000-0003-4479-0641)
- Olivıer Turrini (ORCID: https://orcid.org/0000-0002-2144-2380)
- Marco Del Chiaro (ORCID: https://orcid.org/0000-0002-7400-013X)
- Stefano Crippa (ORCID: https://orcid.org/0000-0002-7370-1508)
- Naoto Gotohda (ORCID: https://orcid.org/0000-0002-4468-5844)
- Jo Nishino (ORCID: https://orcid.org/0000-0001-7057-3048)
- Elisabetta Sereni
- Kimitaka Tanaka (ORCID: https://orcid.org/0000-0001-9899-4581)
- Daniel Pietrasz (ORCID: https://orcid.org/0000-0002-0643-9917)
- Massimo Falconi (ORCID: https://orcid.org/0000-0001-9654-7243)
- Alessandro Coppola (ORCID: https://orcid.org/0000-0002-5550-1756)
- Vismaya S. Bachu
- Oliver Strobel (ORCID: https://orcid.org/0000-0001-5100-8449)
- Eran van Veldhuisen (ORCID: https://orcid.org/0000-0002-5664-2286)
- Quisette P. Janssen (ORCID: https://orcid.org/0000-0002-9353-8293)
- Martijn W.J. Stommel (ORCID: https://orcid.org/0000-0002-4257-5254)
- Simone Augustinus (ORCID: https://orcid.org/0000-0002-0625-4349)
- Geert Kazemier (ORCID: https://orcid.org/0000-0002-9811-3497)
- Jean‐Baptiste Bachet (ORCID: https://orcid.org/0000-0003-4337-286X)
- Henrique Alexandrino (ORCID: https://orcid.org/0000-0002-0279-9659)
- N. Chatzizacharias (ORCID: https://orcid.org/0000-0002-4864-189X)
- Giulio Belfiori (ORCID: https://orcid.org/0000-0001-7334-2878)
- Michael G. House (ORCID: https://orcid.org/0000-0002-1676-8124)
- Michael Bau Mortensen (ORCID: https://orcid.org/0000-0002-7270-5005)
- Atsushi Oba
- Arto Kokkola (ORCID: https://orcid.org/0000-0002-8286-0666)
- Kevin C. Conlon (ORCID: https://orcid.org/0000-0002-3703-7080)
- Toshitaka Sugawara (ORCID: https://orcid.org/0000-0001-7211-6094)
- Alain Sauvanet (ORCID: https://orcid.org/0000-0002-7436-5999)
- Per Pfeiffer (ORCID: https://orcid.org/0000-0002-2925-0586)
- António Sá Cunha (ORCID: https://orcid.org/0000-0003-4015-5368)
- Roberto Salvia (ORCID: https://orcid.org/0000-0002-3514-8473)
- Felix Rückert (ORCID: https://orcid.org/0000-0003-0301-8479)
- Alessandro Zerbi (ORCID: https://orcid.org/0000-0002-9176-0448)
- Trang K. Nguyen (ORCID: https://orcid.org/0000-0002-6619-9724)
- Mickaël Lesurtel (ORCID: https://orcid.org/0000-0003-2397-4599)
- Marco V. Marino (ORCID: https://orcid.org/0000-0002-0466-4467)
- Sohei Satoi (ORCID: https://orcid.org/0000-0001-6527-5409)
- Richard D. Schulick (ORCID: https://orcid.org/0000-0001-7360-7338)
- Alberto Balduzzi (ORCID: https://orcid.org/0000-0001-6018-8816)
- Jing He (ORCID: https://orcid.org/0000-0002-1954-2892)
- Wells A. Messersmith (ORCID: https://orcid.org/0000-0003-2349-0885)
- Timo Tarvainen (ORCID: https://orcid.org/0000-0002-4721-7149)
- Dyre Kleive (ORCID: https://orcid.org/0000-0002-7072-8422)
- Oskar Franklin (ORCID: https://orcid.org/0000-0002-0376-4140)
- Alexis Laurent (ORCID: https://orcid.org/0000-0003-1372-0843)
- Oonagh Griffin (ORCID: https://orcid.org/0000-0003-2326-3009)
- Sjors Klompmaker (ORCID: https://orcid.org/0000-0002-1161-7845)
- José Manuel Ramia (ORCID: https://orcid.org/0000-0003-1186-953X)
- Antonino Mirabella (ORCID: https://orcid.org/0000-0002-2173-6397)
- Ammar A. Javed (ORCID: https://orcid.org/0000-0002-5463-5250)
- Salvador Rodriguez Franco (ORCID: https://orcid.org/0000-0001-9786-3651)
- Jacob L. van Dam (ORCID: https://orcid.org/0000-0002-6947-9035)
- Boris V. Janssen (ORCID: https://orcid.org/0000-0001-5678-1510)
- Romain Coriat (ORCID: https://orcid.org/0000-0003-4420-8340)
- Elena Rangelova (ORCID: https://orcid.org/0000-0003-3844-7265)
- Vincent Dubray
- Isabel M. Feld
- Yu Takahashi
- William R. Burns (ORCID: https://orcid.org/0000-0002-3049-4377)
- Toru Nakamura (ORCID: https://orcid.org/0000-0003-3999-9627)
- Satoshi Hirano (ORCID: https://orcid.org/0000-0001-5392-8337)
- Hirofumi Ishida
- Minoru Tanabe (ORCID: https://orcid.org/0000-0003-4875-1471)
- Nicolas Régenet (ORCID: https://orcid.org/0000-0003-2071-3238)
- Szűcs Attila
- Martin Varga
- Frederik Berrevoet
- Andrej Nikov
- Yan‐Dong Wu
- Mohammed Al-Musawi
- Akio Saiura
- Johanna W. Wilmink
- Yosuke Inoue
- Giovanni Butturini
- Isabella Frigerio
- Claudia E. Mack
Institutions
- Université Paris-Sud (FR)
- University of Verona (IT)
- Tokyo Medical and Dental University (JP)
- Oslo University Hospital (NO)
- Virginia Mason Medical Center (US)
- University of Helsinki (FI)
- Johns Hopkins University (US)
- Vita-Salute San Raffaele University (IT)
- Universität Hamburg (DE)
- University of Oslo (NO)
- Université Paris Cité (FR)
- Aix-Marseille Université (FR)
- Heidelberg University (DE)
- Université Paris-Saclay (FR)
- Hôpital Beaujon (FR)
- Johns Hopkins Medicine (US)
- Helsinki University Hospital (FI)
- Odense University Hospital (DK)
- University Hospital Heidelberg (DE)
- Copenhagen University Hospital (DK)
- Rigshospitalet (DK)
- National Cancer Centre Japan (JP)
- Ospedale Vincenzo Cervello (IT)
- University Medical Center Hamburg-Eppendorf (DE)
- St. Vincent's University Hospital (IE)
- Hospital General Universitario de Alicante Doctor Balmis (ES)
- Erasmus MC Cancer Institute (NL)
- Institut Paoli-Calmettes (FR)
- Amsterdam University Medical Centers (NL)
- Sidney Kimmel Comprehensive Cancer Center (US)
- Japanese Foundation For Cancer Research (JP)
- Cancer Center Amsterdam (NL)
- Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele (IT)
- University of Colorado Anschutz Medical Campus (US)
- Martin Luther University Halle-Wittenberg (DE)
- Medical University of Vienna (AT)
- University of Amsterdam (NL)
- Umeå University (SE)
- University of Colorado Denver (US)
Publication Details
- Journal
- JAMA Oncology
- Published
- 2025-01-23
- DOI
- https://doi.org/10.1001/jamaoncol.2024.5917
- Citations
- 9
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 9.41
Funders
- Aix-Marseille Université
- Amsterdam University Medical Centers
- Universiteit van Amsterdam
- Gentofte Hospital
- Universität Wien
- Odense Universitetshospital
- Umeå Universitet
- Rigshospitalet
- Universitetet i Oslo
- Medizinische Universität Wien
- Università degli Studi di Verona
- Universitätsklinikum Heidelberg
- University of Colorado School of Medicine, Anschutz Medical Campus