Increased nerve density adversely affects outcome in colorectal cancer and denervation suppresses tumor growth
PNI and NND are critical factors influencing CRC patient survival and enhance the accuracy of survival prediction models. Moreover, chemical denervation effectively inhibits rectal tumor growth in vivo, highlighting the potential of neural targeting as a therapeutic strategy in CRC.
Authors
- Minhao Yu (ORCID: https://orcid.org/0000-0001-6058-0586)
- Kexin He
- Yuan Gao (ORCID: https://orcid.org/0000-0003-3777-140X)
- Junli Xue (ORCID: https://orcid.org/0000-0002-0564-5284)
- Ruixue Huo
- Hao Wang (ORCID: https://orcid.org/0000-0001-5694-1203)
- Weihan Li (ORCID: https://orcid.org/0000-0003-4718-1884)
- Shu-Heng Jiang
- Wei He (ORCID: https://orcid.org/0000-0002-3100-9724)
Institutions
- Tongji University (CN)
- Shanghai Jiao Tong University (CN)
- Renji Hospital (CN)
- Shanghai Cancer Institute (CN)
- Shanghai East Hospital (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-01-23
- DOI
- https://doi.org/10.1186/s12967-025-06104-2
- Citations
- 11
- Primary Topic
- Cancer, Stress, Anesthesia, and Immune Response
- Type
- article
- Field-Weighted Citation Impact
- 16.18
Funders
- National Natural Science Foundation of China
- Chinese Society of Clinical Oncology