ROCK Inhibitor Enhances Resilience Against Metabolic Stress Through Increasing Bioenergetic Capacity in Corneal Endothelial Cells
ROCK inhibitor Y27632 enhances the bioenergetic capacity of BCECs, allowing the cells to better withstand metabolic stress by rapidly generating ATP to meet increased energy demands, maintaining ion homeostasis and reducing apoptosis.
Authors
- Muh‐Hwa Yang (ORCID: https://orcid.org/0000-0002-8918-1244)
- Tzuu‐Shuh Jou (ORCID: https://orcid.org/0000-0003-4341-5137)
- I‐Jong Wang (ORCID: https://orcid.org/0000-0002-3045-0614)
- Tsan‐Chi Chen (ORCID: https://orcid.org/0000-0001-5221-9707)
- Wei‐Ting Ho (ORCID: https://orcid.org/0000-0001-8322-0348)
- Jung‐Shen Chang
- Chenyang Lei (ORCID: https://orcid.org/0000-0002-5397-4541)
- Shu-Wen Chang
- Jia-Kang Wang
Institutions
- National Yang Ming Chiao Tung University (TW)
- National Taiwan University (TW)
- Taipei Veterans General Hospital (TW)
- Far Eastern Memorial Hospital (TW)
- National Taiwan University Hospital (TW)
- National Yang Ming Chiao Tung University (TW)
- Yuan Ze University (TW)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-01-23
- DOI
- https://doi.org/10.1167/iovs.66.1.51
- Citations
- 5
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 4.68
Funders
- Far Eastern Memorial Hospital
- National Science and Technology Council