Mechanical Strain of Corneal Epithelium Influences the Expression of Genes Implicated in Keratoconus
We provide a molecular explanation for how mechanical strain results in reduced expression of WNT10A in the corneal epithelium, which, in turn, leads to depletion of collagen type I and XII, and TGFβ1 expression. These results provide a molecular link among mechanical strain, WNT10A expression, and the biomechanical failure of the keratoconus cornea.
Authors
- Charles G. Eberhart (ORCID: https://orcid.org/0000-0002-2910-9427)
- Jiangxia Wang (ORCID: https://orcid.org/0000-0002-1715-3981)
- Uri Soiberman (ORCID: https://orcid.org/0000-0002-1678-6437)
- Loren Moon (ORCID: https://orcid.org/0000-0003-0216-9443)
- Akrit Sodhi (ORCID: https://orcid.org/0000-0001-5441-1014)
- Pritpal Kaur
Institutions
- Johns Hopkins University (US)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-01-23
- DOI
- https://doi.org/10.1167/iovs.66.1.52
- Citations
- 2
- Primary Topic
- Corneal surgery and disorders
- Type
- article
- Field-Weighted Citation Impact
- 2.72
Funders
- Research to Prevent Blindness