Insights into the role of adipose tissue-derived microRNAs in intercellular communication during cardiometabolic diseases

microRNAs (miRNAs) secreted by the adipose tissue (AT) have gained substantial attention over the last decade. Adipocytes produce and secrete large amounts of miRNAs that, in turn, can mediate physiological processes paracrinally or in distant organs. It is now clear that AT-derived miRNAs are important players in the development of obesity-associated comorbidities. Here, we provide an overview that supports this notion and bring insights into the intricate involvement of AT-derived miRNAs in the pathogenesis of cardiometabolic diseases, discussing some of their far-reaching effects on the liver, heart, vasculature, and other tissues. Moreover, we outline future research directions addressing current gaps in the field which we hope will further advance our comprehension of the role of AT-derived miRNAs.