High fructose rewires gut glucose sensing via glucagon-like peptide 2 to impair metabolic regulation in mice
Excess fructose impairs blood glucose and liver homeostasis by rewiring gut glucose sensing and exacerbating gut glucose absorption. Our findings are positioned to inform novel early diagnostic tools and treatments tailored to counter high fructose-induced metabolic derangements predisposing to T2D and MASLD.
Authors
- Fernando F. Anhê (ORCID: https://orcid.org/0000-0003-1543-4154)
- Paulo Henrique Evangelista-Silva (ORCID: https://orcid.org/0000-0002-5491-7354)
- Caio Jordão Teixeira (ORCID: https://orcid.org/0000-0002-4951-1130)
- Patricia Mitchell (ORCID: https://orcid.org/0000-0002-6159-1778)
- Eya Sellami
- Khoudia Diop
Institutions
- Lung Institute (US)
- Université Laval (CA)
Publication Details
- Journal
- Molecular Metabolism
- Published
- 2025-01-22
- DOI
- https://doi.org/10.1016/j.molmet.2025.102101
- Citations
- 5
- Primary Topic
- Diet, Metabolism, and Disease
- Type
- article
- Field-Weighted Citation Impact
- 6.47
Funders
- Fondation Institut Universitaire de Cardiologie et de Pneumologie de Québec
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Institut universitaire de cardiologie et de pneumologie de Québec, Université Laval
- Fonds de Recherche du Québec - Santé