The GacS/GacA two-component system strongly regulates antimicrobial competition mechanisms of <i>Pseudomonas fluorescens</i> MFE01 strain
Our model strain <i>Pseudomonas fluorescens</i> MFE01 uses an active type VI secretion system (T6SS) and volatile compounds (VCs) to outcompete other microorganisms in the natural environment. By investigating the cellular mechanism regulating the production of these weapons, we identified the two-component system GacS/GacA. Indeed, GacS cellular membrane sensor plays a crucial role in regulating T6SS activity and VC emission. Among the latter, 1-undecene and hydrogen cyanide are strong aerial inhibitors of the <i>Legionella</i> human pathogen and the <i>Phytophtora infestans</i> major plant pest, respectively. The aim is to improve the understanding of the regulation of these volatile molecule emission and the critical role of a global regulator in both plant and human health.
Authors
- Corinne Barbey
- Xavier Latour (ORCID: https://orcid.org/0000-0003-0819-0403)
- Annabelle Mérieau (ORCID: https://orcid.org/0000-0003-4320-6562)
- Yvann Bourigault (ORCID: https://orcid.org/0009-0007-5628-4048)
- Julien Verdon (ORCID: https://orcid.org/0000-0002-9722-8719)
- Amine M. Boukerb (ORCID: https://orcid.org/0000-0002-8349-6739)
- Charly Dupont (ORCID: https://orcid.org/0009-0000-3789-1618)
- Héloise Bizière-Maco
Institutions
- Université de Sherbrooke (CA)
- Biocon (Switzerland) (CH)
- Université de Poitiers (FR)
- Agroécologie (FR)
- Normandie Université (FR)
- Écologie et Biologie des Interactions (FR)
- Communication Bactérienne et Stratégie Anti-infectieuses
- Université de Rouen Normandie (FR)
Publication Details
- Journal
- Journal of Bacteriology
- Published
- 2025-01-23
- DOI
- https://doi.org/10.1128/jb.00388-24
- Citations
- 8
- Primary Topic
- Vibrio bacteria research studies
- Type
- article
- Field-Weighted Citation Impact
- 14.38