Population pharmacokinetic analysis of teicoplanin in paediatric patients, including those receiving continuous kidney replacement therapy: a prospective cohort study
This population model is a good proof of concept to develop modelling approaches that could help in an individualized dosing approach that needs to be adopted in critically ill paediatric patients. The standard paediatric dosage for teicoplanin could be insufficient for optimal exposure, and higher doses may benefit both CKRT and non-CKRT patients.
Authors
- Sarah N. Fernández (ORCID: https://orcid.org/0000-0003-4859-5966)
- Vicente Vicente (ORCID: https://orcid.org/0000-0002-4278-3264)
- María Slöcker-Barrio (ORCID: https://orcid.org/0000-0001-7338-9115)
- Laura Butragueño Laiseca (ORCID: https://orcid.org/0000-0001-5430-0488)
- María José Santiago (ORCID: https://orcid.org/0000-0001-8149-1179)
- Natalia Riva (ORCID: https://orcid.org/0000-0001-8359-4040)
- Iñaki F. Trocóniz (ORCID: https://orcid.org/0000-0003-3700-8658)
- Belén Padilla
- Gastón García-Orueta
Institutions
- Universidad Complutense de Madrid (ES)
- Instituto de Salud Carlos III (ES)
- Hospital General Universitario Gregorio Marañón (ES)
- Navarre Institute of Health Research (ES)
- Departamento de Salud (ES)
- Universidad de Navarra (ES)
Publication Details
- Journal
- Journal of Antimicrobial Chemotherapy
- Published
- 2025-01-23
- DOI
- https://doi.org/10.1093/jac/dkaf012
- Citations
- 4
- Primary Topic
- Antibiotics Pharmacokinetics and Efficacy
- Type
- article
- Field-Weighted Citation Impact
- 5.58
Funders
- Instituto de Salud Carlos III
- European Regional Development Fund