Anticancer Properties of Phenylboronic Acid in Androgen-Dependent (LNCaP) and Androgen-Independent (PC3) Prostate Cancer Cells via MAP Kinases by 2D and 3D Culture Methods
PBA exerts antimitotic effects by inhibiting proliferation and migration and triggers diverse metabolic responses across different cell lines. Furthermore, PBA's low toxicity on RWPE-1 cells suggests its potential as a promising chemotherapeutic agent for future studies.
Authors
- Duygu Gürsoy Gürgen (ORCID: https://orcid.org/0000-0001-6698-9032)
- İlknur Keskin (ORCID: https://orcid.org/0000-0002-7059-1884)
- Seda Karabulut (ORCID: https://orcid.org/0000-0003-3302-5004)
- Arife Ahsen Kaplan (ORCID: https://orcid.org/0000-0002-6984-3079)
- Oğuzhan Köse (ORCID: https://orcid.org/0000-0003-2128-0841)
- Arzu Güneş (ORCID: https://orcid.org/0000-0003-2496-7673)
- M. Başak Tunalı (ORCID: https://orcid.org/0000-0002-0928-0462)
Institutions
- Istanbul Medipol University (TR)
- Istanbul University-Cerrahpaşa (TR)
- Istanbul University (TR)
Publication Details
- Journal
- Anti-Cancer Agents in Medicinal Chemistry
- Published
- 2025-01-22
- DOI
- https://doi.org/10.2174/0118715206352302241227031015
- Primary Topic
- Prostate Cancer Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00