Clinical Validation of MyProstateScore 2.0 Testing Using First-Catch, Non–Digital Rectal Examination Urine
Using first-catch urine, MPS2 meaningfully improved the proportion of biopsies avoided relative to PCPTrc while maintaining highly sensitive detection of GG ≥ 2 cancer. Non-DRE testing provides a convenient, objective, and highly accurate testing option to reduce the need for imaging and biopsy in men with elevated PSA.
Authors
- Yuping Zhang (ORCID: https://orcid.org/0000-0002-4374-8831)
- Jeffrey J. Tosoian (ORCID: https://orcid.org/0000-0002-7614-9931)
- Todd Matthew Morgan (ORCID: https://orcid.org/0000-0002-1140-0603)
- Zoey Chopra (ORCID: https://orcid.org/0000-0002-6349-2431)
- Ashley E. Ross (ORCID: https://orcid.org/0000-0001-7044-9688)
- Ganesh S. Palapattu (ORCID: https://orcid.org/0000-0002-9520-0480)
- John Wei (ORCID: https://orcid.org/0000-0002-9426-2727)
- Udit Singhal (ORCID: https://orcid.org/0000-0002-3928-9476)
- Daniel A. Barocas (ORCID: https://orcid.org/0000-0002-7775-9205)
- Jerome Edelson (ORCID: https://orcid.org/0000-0001-8632-648X)
- Simpa S. Salami (ORCID: https://orcid.org/0000-0001-7461-7079)
- Grace Herron (ORCID: https://orcid.org/0009-0008-4591-3192)
- Nathan J. Graham (ORCID: https://orcid.org/0000-0002-2648-4838)
- Lanbo Xiao (ORCID: https://orcid.org/0000-0002-1614-8806)
- Jacob I. Meyers
- Spencer Heaton
- Arul M. Chinnaiyan
- Javed Siddiqui (ORCID: https://orcid.org/0009-0004-8251-4829)
- Keavash Assani
Institutions
- Northwestern University (US)
- Howard Hughes Medical Institute (US)
- Vanderbilt University (US)
- University of Michigan (US)
- University of Chicago (US)
- Vanderbilt-Ingram Cancer Center
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- The Journal of Urology
- Published
- 2025-04-09
- DOI
- https://doi.org/10.1097/ju.0000000000004421
- Citations
- 6
- Primary Topic
- Colorectal Cancer Screening and Detection
- Type
- article
- Field-Weighted Citation Impact
- 6.27
Funders
- Prostate Cancer Foundation
- Pfizer
- Vanderbilt University
- University of Michigan
- Boston Scientific Corporation
- Veracyte
- Astellas Pharma
- National Institutes of Health
- National Institute on Aging
- National Cancer Institute