Plasmalogens Activate AKT/mTOR Signaling to Attenuate Reactive Oxygen Species Production in Spinal Cord Injury
Plasmalogens reduce ROS levels and regulate inflammation-induced damage, contributing to neuroprotection. This study reveals that plasmalogens promote remyelination, reduce axonal degeneration and neuronal apoptosis, and-used here for the first time in spinal cord injury repair- may protect neurons by reducing ROS levels and activating the AKT/mTOR signaling pathway.
Authors
- Xiaojie Lu
- Liangliang Zhang (ORCID: https://orcid.org/0000-0002-5091-018X)
- Xu Bai (ORCID: https://orcid.org/0000-0002-6990-1363)
- Yan Gao (ORCID: https://orcid.org/0000-0003-0279-0790)
- Yiqing Wu (ORCID: https://orcid.org/0000-0002-3021-1381)
- Mengdan Cheng
Institutions
- Jiangnan University (CN)
- Handan College (CN)
- Wuxi Institute of Technology (CN)
Publication Details
- Journal
- Current Gene Therapy
- Published
- 2025-01-22
- DOI
- https://doi.org/10.2174/0115665232330349241225074627
- Primary Topic
- Spinal Cord Injury Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00