Nutritional Evaluation and Free Radical Scavenging Activity of Nano-formulated Selenium-Moringa Peregrine Seed Extract as a Promising Suppressor of TGF-β1/P38/NF-kβ Signaling Pathway in HgCl <sub>2</sub> Intoxicated-mice
The study reveals that Moringa peregrina extract combined with selenium nanoparticles (MPESeNPs) offers significant protection against oxidative damage induced by HgCl₂ exposure. The enhanced antioxidant and anti-inflammatory properties of MPE-SeNPs, particularly at a dose of 38.65 mg/kg body weight, demonstrate their potential as a powerful natural therapy for pulmonary fibrosis. These findings underscore the promise of MPE-SeNPs in improving lung health by mitigating oxidative stress, reducing inflammation, and promoting tissue repair, paving the way for innovative treatments in respiratory medicine.
Authors
- Samar Aborhyem (ORCID: https://orcid.org/0000-0002-1025-7876)
- Mohammed A. Hussein (ORCID: https://orcid.org/0000-0002-1811-2794)
- Mahmoud El-Tawila
- Reham A. Hamdy
Institutions
- October 6 University (EG)
- Alexandria University (EG)
Publication Details
- Journal
- Current Pharmaceutical Biotechnology
- Published
- 2025-01-22
- DOI
- https://doi.org/10.2174/0113892010352642241221152820
- Primary Topic
- Moringa oleifera research and applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00