In Vitro α/β Ratio Variations in Cervical Cancer, with Consequent Effects on Equivalent Dose in 2 Gy Fraction in High-Dose-Rate Brachytherapy
There was large variation in <i>in vitro</i> α/β values which presented as a right-skewed log-normal distribution with a most probable value of ∼4.3 Gy for cervical cancer. Adenocarcinoma showed somewhat lower average α/β values compared with squamous cell carcinoma, but the difference was not substantial enough to draw definitive conclusions. Lower α/β values resulted in higher EQD<sub>2</sub> for HDR-BT compared with α/β values at 10 Gy. This suggests that more accurate and potentially lower α/β values should be used for cervical cancer.
Authors
- William St Clair
- Dennis Cheek (ORCID: https://orcid.org/0000-0002-7578-1687)
- Brien Washington
- Cameron Thayer-Freeman
- Mark E. Bernard (ORCID: https://orcid.org/0009-0000-6756-5207)
- Wei Luo (ORCID: https://orcid.org/0000-0002-3474-3465)
- Denise Fabian
Institutions
- University of Kentucky (US)
- Southwestern Medical Center (US)
- Southwestern Medical Center (US)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- Advances in Radiation Oncology
- Published
- 2025-01-23
- DOI
- https://doi.org/10.1016/j.adro.2025.101725
- Citations
- 2
- Primary Topic
- Endometrial and Cervical Cancer Treatments
- Type
- article
- Field-Weighted Citation Impact
- 4.11