<scp>DECORIN</scp> , a triceps‐derived myokine, protects sorted β‐cells and human islets against chronic inflammation associated with type 2 diabetes
Collectively, we have shown that DECORIN had a beneficial effect on human islets, protecting them from inflammation-induced cell death. In T2D islets, DECORIN restores islet function and reverses the expression of T2D-associated genes. Based on our data, we propose that DECORIN is a promising therapeutic target for diabetes-associated inflammation and diabetes itself.
Authors
- Siobhan M. Craige
- Emmanuelle Meugnier (ORCID: https://orcid.org/0000-0002-2291-7691)
- Karim Bouzakri (ORCID: https://orcid.org/0000-0002-0703-5105)
- Bader Zarrouki
- Ali Rida
- A. Langlois (ORCID: https://orcid.org/0009-0006-0178-0098)
- Bernhard Wehrle‐Haller (ORCID: https://orcid.org/0000-0002-1159-1147)
- C. Péronet
- Caroline Arous (ORCID: https://orcid.org/0000-0002-0677-8767)
- M. Pinget
- Julien Cherfan
- Harzo Hamdard
Institutions
- Université Claude Bernard Lyon 1 (FR)
- University of Geneva (CH)
- Inserm (FR)
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
- Hospices Civils de Lyon (FR)
- AR2i (FR)
- Laboratoire de recherche en cardiovasculaire, métabolisme, diabétologie et nutrition (FR)
- Université de Strasbourg (FR)
- Virginia Tech (US)
Publication Details
- Journal
- Acta Physiologica
- Published
- 2025-01-22
- DOI
- https://doi.org/10.1111/apha.14267
- Citations
- 5
- Primary Topic
- Pancreatic function and diabetes
- Type
- article
- Field-Weighted Citation Impact
- 10.03