Interaction of B0AT1 Deficiency and Diet on Metabolic Function and Diabetes Incidence in Male Nonobese Diabetic Mice
Dietary composition does, but B0AT1 deficiency does not, affect autoimmune diabetes incidence in male NOD mice. B0AT1 deficiency, however, reduces diet-induced metabolic dysfunction and in HFHP-fed mice increases pancreatic β-cell clusters and small islets.
Authors
- Kiran Javed (ORCID: https://orcid.org/0000-0003-2058-4798)
- Christopher J. Nolan (ORCID: https://orcid.org/0000-0002-6964-3819)
- Muhammad Shamoon (ORCID: https://orcid.org/0000-0003-0496-3544)
- Viviane Delghingaro‐Augusto (ORCID: https://orcid.org/0000-0002-5107-2384)
- Jane E. Dahlstrom (ORCID: https://orcid.org/0000-0001-5608-693X)
- Gaétan Burgio (ORCID: https://orcid.org/0000-0002-7434-926X)
- Stefan Bröer (ORCID: https://orcid.org/0000-0002-8040-1634)
- Matthew F. Waters (ORCID: https://orcid.org/0000-0001-7334-9295)
Institutions
- Australian National University (AU)
- Canberra Hospital (AU)
Publication Details
- Journal
- Endocrinology
- Published
- 2025-01-23
- DOI
- https://doi.org/10.1210/endocr/bqaf016
- Citations
- 1
- Primary Topic
- Pancreatic function and diabetes
- Type
- article
- Field-Weighted Citation Impact
- 2.01
Funders
- Medical Research Council
- National Health and Medical Research Council