Novel [3+2+1] Coordinated Iridium (III) Complexes for Hyperefficient Photodynamic Therapy

ABSTRACT Efficient photosensitizers are crucial for the success of photodynamic therapy (PDT). Herein, we reported two [3+2+1] coordinated organometallic Iridium (III) complexes (labeled as Ir‐C1 and Ir‐C4 ). Ir‐C1 / C4 can generate both type I and type II reactive oxygen species (ROS). In vitro experiments, Ir‐C1 / C4 show low biotoxicity and high phototoxicity of half‐maximal inhibitory concentration values of 14 nM and 33 nM on rectal cancer cell line HCT116, respectively. Western blot analysis revealed that the Ir‐C1 / C4 activated ferroptosis, apoptosis, and inhibiting autophagy simultaneously. Proteomics analysis demonstrated that the photosensitizers destroyed the endoplasmic reticulum (ER), blocking the signal transmission and material transfer between the ER and other tissues of the cell, especially the ER to Golgi vesicle‐mediated transport. Ir‐C1 / C4 can achieve better antitumor performance than commercial photosensitizer Chlorin e6 and the ferroptosis activator RSL3 at lower concentrations. The low biotoxicity and high phototoxicity make them ideal candidates for PDT. The findings provide new insights into the design of photosensitizers for metal complexes and have significant implications for the development of PDT and related drugs.

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Published
2025-01-22
DOI
https://doi.org/10.1002/agt2.710
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9
Primary Topic
Nanoplatforms for cancer theranostics
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article
Field-Weighted Citation Impact
6.07

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article

Novel [3+2+1] Coordinated Iridium (III) Complexes for Hyperefficient Photodynamic Therapy

Wu Yuan, Yufeng Gao, Jinhui Jiang, Chen Yang et al.
9 citations
Aggregate
Nanoplatforms for cancer theranostics
6.07
article

Novel [3+2+1] Coordinated Iridium (III) Complexes for Hyperefficient Photodynamic Therapy

Wu Yuan, Yufeng Gao, Jinhui Jiang, Chen Yang, Ming Shao, Jacky W. Y. Lam, Juan Du, Zheng Qing Zhao, Xi‐Ling Xu, Ben Zhong Tang, Chao Chen, Siwei Zhang, Zixin Wang, Fulong Ma
article en
9 citations

Abstract

ABSTRACT Efficient photosensitizers are crucial for the success of photodynamic therapy (PDT). Herein, we reported two [3+2+1] coordinated organometallic Iridium (III) complexes (labeled as Ir‐C1 and Ir‐C4 ). Ir‐C1 / C4 can generate both type I and type II reactive oxygen species (ROS). In vitro experiments, Ir‐C1 / C4 show low biotoxicity and high phototoxicity of half‐maximal inhibitory concentration values of 14 nM and 33 nM on rectal cancer cell line HCT116, respectively. Western blot analysis revealed that the Ir‐C1 / C4 activated ferroptosis, apoptosis, and inhibiting autophagy simultaneously. Proteomics analysis demonstrated that the photosensitizers destroyed the endoplasmic reticulum (ER), blocking the signal transmission and material transfer between the ER and other tissues of the cell, especially the ER to Golgi vesicle‐mediated transport. Ir‐C1 / C4 can achieve better antitumor performance than commercial photosensitizer Chlorin e6 and the ferroptosis activator RSL3 at lower concentrations. The low biotoxicity and high phototoxicity make them ideal candidates for PDT. The findings provide new insights into the design of photosensitizers for metal complexes and have significant implications for the development of PDT and related drugs.

AggregateVol. 6(4)
Shenzhen University (CN), Anhui Medical University (CN), Hong Kong University of Science and Technology (HK), Longgang Central Hospital (CN), Chinese University of Hong Kong, Shenzhen (CN), First Affiliated Hospital of Xi'an Jiaotong University (CN), University of Hong Kong - Shenzhen Hospital (CN), Shenzhen University Health Science Center (CN), Shenzhen Second People's Hospital (CN), University of Hong Kong (HK)
National Natural Science Foundation of China, Innovation and Technology Commission
Openalex Percentile: Top 4%
Nanoplatforms for cancer theranostics
6.07
DOIOpen Access PDFOpenAlex
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