Potential Therapeutic Drug Targets for Hypertension Identified Using Proteomics and Mendelian Randomization
By combining cis-MR analysis with colocalization analysis, we identified ERAP1 and ACVRL1 as potential targets for interventions in the primary prevention of HT, with ERAP1 emerging as a particularly promising drug target after further validation.
Authors
- Chunjin Lin (ORCID: https://orcid.org/0000-0002-0109-1464)
- Liman Wang (ORCID: https://orcid.org/0009-0009-7070-2335)
- Danlian Huang
- Qing Chen (ORCID: https://orcid.org/0000-0002-7360-5700)
- Min Li (ORCID: https://orcid.org/0000-0002-5657-8675)
- Wei Pan (ORCID: https://orcid.org/0000-0001-7353-3498)
- Haozhang Huang
- Huizhen Yu (ORCID: https://orcid.org/0009-0009-7804-1826)
Institutions
- Fujian Medical University (CN)
- Sun Yat-sen University (CN)
- Fujian Provincial Hospital (CN)
- Guangdong Academy of Medical Sciences (CN)
- Guangdong Provincial People's Hospital (CN)
- Eighth Affiliated Hospital of Sun Yat-sen University
- Southern Medical University (CN)
- Fuzhou University (CN)
Publication Details
- Journal
- American Journal of Hypertension
- Published
- 2025-01-23
- DOI
- https://doi.org/10.1093/ajh/hpaf011
- Citations
- 2
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 3.63