In vivo mapping of sodium homeostasis disturbances in individual ALS patients: A brain 23Na MRI study
This study mapping sodium homeostasis disturbances at the individual level in ALS patients through 23Na MRI evidenced heterogeneity of TSC increase among patients associated with clinical presentation and disease severity. These findings suggest that TSC increase detected at the individual level by 23Na MRI may be a useful marker of the clinical heterogeneity of ALS patients, a factor that is likely to greatly influence the results of therapeutic trials.
Authors
- Annie Verschueren (ORCID: https://orcid.org/0000-0003-1266-9062)
- Adil Maarouf
- Aude‐Marie Grapperon (ORCID: https://orcid.org/0000-0002-4196-9374)
- Jean‐Philippe Ranjeva (ORCID: https://orcid.org/0000-0001-8073-102X)
- Wafaa Zaaraoui (ORCID: https://orcid.org/0000-0002-9036-6246)
- Shahram Attarian (ORCID: https://orcid.org/0000-0002-7211-4694)
- Maxime Guye (ORCID: https://orcid.org/0000-0002-4435-2257)
- Mohamed Mounir El Mendili
Institutions
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Aix-Marseille Université (FR)
- Centre de Résonance Magnétique Biologique et Médicale (FR)
- Hôpital de la Timone (FR)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-01-22
- DOI
- https://doi.org/10.1371/journal.pone.0316916
- Citations
- 4
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 5.56
Funders
- Fédération pour la Recherche sur le Cerveau
- Association pour la Recherche sur la Sclérose Latérale Amyotrophique et autres Maladies du Motoneurone