HPV Vaccines: state of the art and novel approaches
High-risk genotypes of Human Papillomavirus (HPV) are responsible for cervical cancer and have been shown to be related to the occurrence of other less frequent malignancies (vulva, penis, anus, head and neck). Although in the majority of cases the infection resolves spontaneously, some people fail to clear the virus with an increased risk of neoplastic development. In Italy, HPV vaccination is recommended and offered free of charge to girls and boys from 11 years of age. It is also recommended for immunocompromised patients, individuals with high risk sexual behavior, and women with cervical lesions. The efficacy of HPV vaccination in preventing cervical cancer, especially in uninfected women, has been widely demonstrated. Further advances in technology to improve the efficacy of existing vaccines and the development of novel vaccines are necessary to prevent HPV-associated cancers. The aim of this non-systematic review is to provide an update on the available vaccines and future perspectives for HPV vaccination
Authors
- Elisabetta Del Duca (ORCID: https://orcid.org/0000-0002-8134-5582)
- Baldassarre Martire
- Veronica Santilli (ORCID: https://orcid.org/0000-0003-1329-6827)
- Mayla Sgrulletti (ORCID: https://orcid.org/0000-0002-7493-5226)
- Giorgio Costagliola (ORCID: https://orcid.org/0000-0002-4160-3727)
- Caterina Rizzo (ORCID: https://orcid.org/0000-0002-5583-7508)
- Viviana Moschese (ORCID: https://orcid.org/0000-0001-7650-0632)
- Giusella Maria Francesca Moscato
- Giorgio Ottaviano (ORCID: https://orcid.org/0000-0003-3777-0394)
- Davide Montin (ORCID: https://orcid.org/0000-0001-8953-2182)
- Alessandra Beni (ORCID: https://orcid.org/0000-0001-6995-4791)
- Maria Felicia Mastrototaro
Institutions
- University of Pisa (IT)
- University of Rome Tor Vergata (IT)
- Ospedale di Rivoli (IT)
- Azienda Ospedaliera San Gerardo (IT)
- Bambino Gesù Children's Hospital (IT)
- Ospedale Regina Margherita (IT)
- Policlinico Tor Vergata (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Azienda Ospedaliera Universitaria Pisana (IT)
- University of Turin (IT)
Publication Details
- Journal
- Rivista di immunologia ed allergologia pediatrica.
- Published
- 2024-10-01
- DOI
- https://doi.org/10.53151/2531-3916/2024-532
- Primary Topic
- Cervical Cancer and HPV Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00