Extracellular matrix turnover in severe COVID-19 is reduced by corticosteroids
Our findings suggest that elevated collagen turnover is associated with poor outcomes in critically ill COVID-19 patients. DEX treatment appeared to attenuate ECM remodeling, although this effect was not linked to improved survival. Further studies are needed to confirm these observations and better understand the role of ECM remodeling in COVID-19 and the potential therapeutic impact of corticosteroids.
Authors
- Simone van der Sar–van der Brugge (ORCID: https://orcid.org/0000-0001-6462-075X)
- Diana Julie Leeming (ORCID: https://orcid.org/0000-0002-4256-140X)
- M.A. Karsdal (ORCID: https://orcid.org/0000-0001-5026-8740)
- Antine Flikweert
- Janette K. Burgess (ORCID: https://orcid.org/0000-0001-9868-9966)
- Jill Moser (ORCID: https://orcid.org/0000-0002-9614-2577)
- Jannie Marie Bülow Sand (ORCID: https://orcid.org/0000-0002-3239-0934)
- Janesh Pillay (ORCID: https://orcid.org/0000-0001-8037-6638)
- Matijs van Meurs (ORCID: https://orcid.org/0000-0002-7745-2772)
- Marco Grootenboers
- Peter H. J. van der Voort
Institutions
- University Medical Center Groningen (NL)
- University of Groningen (NL)
- Amphia Ziekenhuis (NL)
- Nordic Bioscience (Denmark) (DK)
Publication Details
- Journal
- Respiratory Research
- Published
- 2025-01-22
- DOI
- https://doi.org/10.1186/s12931-025-03098-9
- Citations
- 4
- Primary Topic
- COVID-19 Clinical Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 5.58
Funders
- ZonMw
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- Universitair Medisch Centrum Groningen