Multiomics: Concepts, Methods and Applications

Multiomics is a high-throughput technology with multilayered system biology approach incorporating bioinformatic analysis of the data. At present it includes genomics, epigenomics, transcriptomics, proteomics, metabolomics, and gut microbiomics with advancement to the level of single cell analysis. Multiomics is an advancing approach (1) to understand the pathobiology of disease, (2) to identify sensitive biomarkers for the diagnosis of diseases as well as in monitoring and (3) to identify disease specific targets to treat the patient in the context of precision medicine as targeted therapeutics. In the present review, a brief account of various multiomic techniques is considered and relevant examples are pondered to reflect their applications in both preclinical and clinical translational research.