APOE Christchurch enhances a disease-associated microglial response to plaque but suppresses response to tau pathology
These findings highlight the ability of the ApoeCh variant to modulate microglial responses based on the type of pathology, enhancing DAM reactivity in amyloid models and dampening neuroinflammation to promote protection in tau models. This suggests that the Christchurch variant's protective effects likely involve multiple mechanisms, including changes in receptor binding and microglial programming.
Authors
- Sherilyn Collins
- Ángela Gómez-Arboledas (ORCID: https://orcid.org/0000-0001-9636-9512)
- Nellie Kwang (ORCID: https://orcid.org/0000-0001-8890-4976)
- Nicholas T. Seyfried (ORCID: https://orcid.org/0000-0002-4507-624X)
- Kai‐Xuan Shi
- Frank M. LaFerla (ORCID: https://orcid.org/0000-0003-2324-6911)
- Andrea J. Tenner (ORCID: https://orcid.org/0000-0003-3000-024X)
- Zechuan Shi (ORCID: https://orcid.org/0000-0002-2844-5816)
- Kristine M. Tran (ORCID: https://orcid.org/0000-0002-4444-7221)
- Vivek Swarup (ORCID: https://orcid.org/0000-0003-3762-2746)
- Shimako Kawauchi (ORCID: https://orcid.org/0000-0002-8577-4763)
- Duc Minh Duong (ORCID: https://orcid.org/0000-0001-5880-1888)
- Rocio A. Barahona (ORCID: https://orcid.org/0000-0003-1654-6377)
- Kim N. Green (ORCID: https://orcid.org/0000-0002-6049-6744)
- Celia Da Cunha
- Grant R. MacGregor (ORCID: https://orcid.org/0000-0001-7598-9501)
- Joshua A. Alcantara (ORCID: https://orcid.org/0000-0002-7970-8970)
- Lindsay A. Hohsfield (ORCID: https://orcid.org/0000-0002-6018-656X)
- Claire A. Butler (ORCID: https://orcid.org/0000-0001-9320-8297)
- Kate I. Tsourmas (ORCID: https://orcid.org/0000-0001-8588-501X)
- Shuling Wang (ORCID: https://orcid.org/0000-0002-3517-2588)
- Cassandra Mar
- Donna Chao
- Jonathan Neumann
- Amber Walker
Institutions
- Emory University (US)
- University of California, Irvine (US)
- Abterra Biosciences (United States) (US)
Publication Details
- Journal
- Molecular Neurodegeneration
- Published
- 2025-01-22
- DOI
- https://doi.org/10.1186/s13024-024-00793-x
- Citations
- 11
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 9.26
Funders
- National Institutes of Health
- University of California, Irvine
- National Institute on Aging
- National Cancer Institute