Vaccination of mice with Trichinella spiralis C-type lectin elicited the protective immunity and enhanced gut epithelial barrier function
Vaccination of mice with rTsCTL elicited an obvious protective immunity against larval challenge, impeded larval invasion of gut mucosa, enhanced gut epithelial integrity and barrier function, reduced worm burdens; it also alleviated gut and muscle inflammation. TsCTL might be a novel candidate target molecule for anti-Trichinella vaccines.
Authors
- Ruo Dan Liu (ORCID: https://orcid.org/0000-0003-3451-9540)
- Xin Zhuo Zhang (ORCID: https://orcid.org/0009-0003-3576-8220)
- Bo Ning Wang
- Jing Cui (ORCID: https://orcid.org/0000-0001-8726-5498)
- Wen Wen Zheng
- Shao Rong Long
- Zhong Quan Wang (ORCID: https://orcid.org/0000-0001-9376-9975)
- Zhao Yu Zhang
- Pei Kun Cong
- Jin Yi Wu
Institutions
- Zhengzhou University (CN)
Publication Details
- Journal
- PLoS neglected tropical diseases
- Published
- 2025-01-22
- DOI
- https://doi.org/10.1371/journal.pntd.0012825
- Citations
- 3
- Primary Topic
- Parasitic Diseases Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 4.19
Funders
- National Natural Science Foundation of China
- Zhengzhou University