Clonal hematopoiesis of indeterminate potential and type 2 diabetes mellitus among patients with STEMI: from a prospective cohort study combing bidirectional Mendelian randomization
CHIP mutations, particularly TET2, are more prevalent in patients with T2DM compared to individuals without diabetes. The presence of these mutations is associated with adverse clinical outcomes, notably increased mortality rates. Moreover, bidirectional Mendelian randomization analyses provide supporting evidence for a potential causal relationship between TET2-related CHIP and the development of T2DM.
Authors
- Jiannan Li (ORCID: https://orcid.org/0000-0001-9744-7666)
- Peng Zhou (ORCID: https://orcid.org/0000-0002-3675-4985)
- Hongbing Yan (ORCID: https://orcid.org/0000-0002-2031-6438)
- Yi Chen (ORCID: https://orcid.org/0009-0009-9770-5632)
- Xiaoxiao Zhao (ORCID: https://orcid.org/0000-0002-8006-6418)
- Runzhen Chen (ORCID: https://orcid.org/0000-0003-1139-495X)
- Jinying Zhou (ORCID: https://orcid.org/0000-0001-5597-4329)
- Li Song (ORCID: https://orcid.org/0000-0001-9078-5742)
- Yu Guang Tan (ORCID: https://orcid.org/0000-0002-8166-0582)
- Chen Liu (ORCID: https://orcid.org/0009-0003-0430-6146)
- Nan Li (ORCID: https://orcid.org/0000-0002-7529-0781)
- Shaodi Yan
- Hanjun Zhao (ORCID: https://orcid.org/0000-0001-6201-4553)
Institutions
- Central South University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Fudan University (CN)
- Zhongshan Hospital (CN)
- Xiangya Hospital Central South University (CN)
- Fu Wai Hospital (CN)
Publication Details
- Journal
- Cardiovascular Diabetology
- Published
- 2025-01-22
- DOI
- https://doi.org/10.1186/s12933-025-02588-w
- Citations
- 4
- Primary Topic
- Acute Myeloid Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 7.08
Funders
- National Natural Science Foundation of China
- Chinese Academy of Medical Sciences