m1A-regulated DIAPH3 promotes the invasiveness of colorectal cancer via stabilization of KRT19
Our study reveals that DIAPH3 mRNA was modified in CRC cells by m1A methylation. Silencing DIAPH3 suppresses the migration and invasion of CRC cells, potentially through the proteasome-dependent degradation of downstream KRT19.
Authors
- Wenwen Chen (ORCID: https://orcid.org/0000-0003-0716-1782)
- Shuyi Mi
- Meng Xue
- Jingyu Chen (ORCID: https://orcid.org/0000-0002-2127-1788)
- Zhipeng Xu (ORCID: https://orcid.org/0000-0001-7957-547X)
- Jie Hu (ORCID: https://orcid.org/0000-0002-4535-3366)
Institutions
- The First People's Hospital of Changde (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Clinical & Experimental Metastasis
- Published
- 2025-01-22
- DOI
- https://doi.org/10.1007/s10585-024-10323-0
- Citations
- 1
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Zhejiang Province