Association between non-insulin-based insulin resistance indicators and frailty progression: a national cohort study and mendelian randomization analysis
The non-insulin-based IR indicators, including TyG index, METS-IR and eGDR, were independently associated with the frailty progression and physical function decline. Monitoring and managing abnormal glucose metabolism should be recommended as a part of comprehensive strategies to prevent or delay the progression of frailty.
Authors
- Y. Li (ORCID: https://orcid.org/0009-0007-2390-1476)
- Ying Lian (ORCID: https://orcid.org/0000-0002-0679-2403)
- Hui Tian (ORCID: https://orcid.org/0000-0002-6334-6389)
- Chengqiang Wang (ORCID: https://orcid.org/0000-0002-2392-7138)
- Guoqiang Chen (ORCID: https://orcid.org/0000-0003-4936-2363)
Institutions
- University of Freiburg (DE)
- Shandong Provincial QianFoShan Hospital (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Cardiovascular Diabetology
- Published
- 2025-01-22
- DOI
- https://doi.org/10.1186/s12933-025-02597-9
- Citations
- 14
- Primary Topic
- Frailty in Older Adults
- Type
- article
- Field-Weighted Citation Impact
- 17.14
Funders
- Natural Science Foundation of Shandong Province