Additive Value of Polygenic Risk Score to Family History for Type 2 Diabetes Prediction: Results From the All of Us Research Database
In predicting T2D, inclusion of a T2D PRS in addition to family history of T2D (first-degree relatives) added statistical value. Further study is needed to determine whether consideration of both family history and a PRS would be useful for clinical T2D prediction.
Authors
- Ramal Moonesinghe (ORCID: https://orcid.org/0000-0001-5327-533X)
- Muin J. Khoury (ORCID: https://orcid.org/0000-0002-9887-443X)
- Alain K. Koyama (ORCID: https://orcid.org/0000-0002-1246-2937)
- Emily Drzymalla (ORCID: https://orcid.org/0009-0007-7258-3777)
- Laura M. Raffield (ORCID: https://orcid.org/0000-0002-7892-193X)
- Meda E. Pavkov (ORCID: https://orcid.org/0000-0002-6203-1772)
- Cassandra Nichole Spracklen (ORCID: https://orcid.org/0000-0003-3590-7182)
- Katherine Kolor
Institutions
- University of North Carolina at Chapel Hill (US)
- Centers for Disease Control and Prevention (US)
- University of Massachusetts Amherst (US)
- Office of Public Health Genomics (US)
- National Center for Chronic Disease Prevention and Health Promotion (US)
Publication Details
- Journal
- Diabetes Care
- Published
- 2025-01-22
- DOI
- https://doi.org/10.2337/dc24-1537
- Citations
- 3
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 5.45