The clinical value of serum sirtuin-1 concentration in the diagnosis of metabolic dysfunction-associated steatotic liver disease
The present study demonstrated that serum Sirt-1 levels were significantly lower in patients with MASLD. Furthermore, these levels were correlated with various metabolic parameters, including insulin resistance and the serum lipid profile. A serum Sirt-1 level below the cutoff of 23.75 ng/mL exhibited a significant association with the presence of MASLD, suggesting its potential utility in identifying patients with this condition.
Authors
- Soudabeh Hamedi−Shahraki (ORCID: https://orcid.org/0000-0003-2270-7421)
- Mahdiyeh Taghizadeh
- Somayyeh Asghari (ORCID: https://orcid.org/0000-0002-0501-0115)
- Banafshe Khalese-Ranjbar
- Farshad Amirkhizi (ORCID: https://orcid.org/0000-0003-1477-0260)
Institutions
- Zabol University of Medical Sciences (IR)
- Tehran University of Medical Sciences (IR)
Publication Details
- Journal
- BMC Gastroenterology
- Published
- 2025-01-22
- DOI
- https://doi.org/10.1186/s12876-025-03613-8
- Citations
- 3
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 4.06
Funders
- Tehran University of Medical Sciences and Health Services