Mechanism of hyperbaric oxygen therapy downregulating H-type angiogenesis in subchondral bone of knee osteoarthritis through the PHD2/HIF-1α pathway
The hyperbaric oxygen environment promotes the expression of PHD2, accelerates the degradation of HIF-1α, and inhibits the production of VEGFA, thereby reducing the generation of type H vessels in subchondral bone.
Authors
- Zhaoxiang Meng
- Yuxin Zhang (ORCID: https://orcid.org/0000-0001-7224-2533)
- Bo Chen (ORCID: https://orcid.org/0000-0003-2506-9875)
- Jianjian Wang (ORCID: https://orcid.org/0000-0002-9989-669X)
- Wen Yu (ORCID: https://orcid.org/0000-0003-0397-6896)
Institutions
- Shanghai Jiao Tong University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Shanghai Ninth People's Hospital (CN)
- Northern Jiangsu People's Hospital (CN)
Publication Details
- Journal
- Journal of Orthopaedic Surgery and Research
- Published
- 2025-01-22
- DOI
- https://doi.org/10.1186/s13018-025-05514-8
- Citations
- 3
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 5.00
Funders
- Jiangsu Commission of Health