Usefulness of serum HBV RNA levels for predicting antiviral response to entecavir treatment in patients with chronic hepatitis B
Serum HBV RNA levels predicted HBeAg seroconversion and early HBV DNA reduction in HBeAg-positive patients, while HBcrAg was significantly associated with virologic response in HBeAg-negative patients. These findings highlight the different predictive roles of HBV RNA and HBcrAg based on HBeAg status, which may provide individualized treatment strategies.
Authors
- Shinsuke Uchikawa (ORCID: https://orcid.org/0000-0002-1538-4946)
- Seiya Kashiyama
- C. Nelson Hayes (ORCID: https://orcid.org/0000-0003-1691-3544)
- Eisuke Murakami (ORCID: https://orcid.org/0000-0003-0357-2795)
- Masataka Tsuge (ORCID: https://orcid.org/0000-0001-7591-8287)
- Tomokazu Kawaoka (ORCID: https://orcid.org/0000-0002-1887-1096)
- Shiro Oka (ORCID: https://orcid.org/0000-0002-1652-0743)
- Daiki Miki (ORCID: https://orcid.org/0000-0002-6505-9826)
- Masanari Kosaka (ORCID: https://orcid.org/0009-0006-6374-4965)
- Atsushi Ono (ORCID: https://orcid.org/0000-0002-2482-945X)
- Hatsue Fujino (ORCID: https://orcid.org/0000-0002-9691-4960)
- Sho Mokuda (ORCID: https://orcid.org/0000-0002-8529-1016)
- Kenji Yamaoka (ORCID: https://orcid.org/0000-0002-9638-359X)
- Shinichi Yamazaki (ORCID: https://orcid.org/0000-0003-0824-5873)
- Yasutoshi Fujii (ORCID: https://orcid.org/0000-0002-3967-6687)
Institutions
- Hiroshima University (JP)
- Hiroshima University Hospital (JP)
Publication Details
- Journal
- Journal of Gastroenterology
- Published
- 2025-01-22
- DOI
- https://doi.org/10.1007/s00535-025-02211-5
- Citations
- 3
- Primary Topic
- Hepatitis B Virus Studies
- Type
- article
- Field-Weighted Citation Impact
- 4.06
Funders
- Japan Agency for Medical Research and Development
- Hiroshima University
- Japan Society for the Promotion of Science