Anti-proliferative and photodynamic activities of Senna didymobotrya (Fresen.) leaf alkaloid-rich extracts against breast cancer cells
Although the in silico analysis suggests that the plant-identified alkaloid phytoconstituents inhibition of estrogen receptor-alpha, human epidermal growth factor receptor-2 and progesterone receptor proteins involved in breast cancer pathogenesis could explain a possible mechanism for the observed anticancer effect, more detailed in vitro molecular experiments are necessary to confirm these findings.
Authors
- Blassan Plackal Adimuriyil George (ORCID: https://orcid.org/0000-0002-7062-4412)
- Kolawole A. Olofinsan (ORCID: https://orcid.org/0000-0002-2987-0996)
- Heidi Abrahamse (ORCID: https://orcid.org/0000-0001-5002-827X)
Institutions
- University of Johannesburg (ZA)
Publication Details
- Journal
- BMC Complementary Medicine and Therapies
- Published
- 2025-01-22
- DOI
- https://doi.org/10.1186/s12906-025-04763-8
- Citations
- 3
- Primary Topic
- Phytochemistry and biological activity of medicinal plants
- Type
- article
- Field-Weighted Citation Impact
- 5.25
Funders
- National Research Foundation
- South African Medical Research Council
- University of Johannesburg
- Medical Research Council
- Division of Research Capacity Development
- CSIR National Laser Centre