DNA methylation profiling at base-pair resolution reveals unique epigenetic features of early-onset colorectal cancer in underrepresented populations
In this study, we provide to the scientific community high-resolution DNA methylomes for a cohort of EOCRC patients from underrepresented populations. Our exploratory findings in this cohort highlight epigenetic mechanisms underlying the pathogenesis of EOCRC and nominate novel biomarkers for EOCRC in underrepresented populations.
Authors
- Neda Zarrin‐Khameh (ORCID: https://orcid.org/0000-0001-7506-156X)
- Michael E. Scheurer (ORCID: https://orcid.org/0000-0002-8379-6088)
- Lanlan Shen (ORCID: https://orcid.org/0000-0002-1532-5807)
- Jason Sheng Li (ORCID: https://orcid.org/0000-0003-0485-7194)
- Chad J. Creighton (ORCID: https://orcid.org/0000-0002-6090-703X)
- Benjamin Musher (ORCID: https://orcid.org/0000-0002-4997-1751)
- Wedad Alfarkh
- Chaorong Chen (ORCID: https://orcid.org/0000-0001-5492-4426)
- Patricia Garrido Castro (ORCID: https://orcid.org/0000-0002-4677-9465)
- Karen Riggins
- Wei Li (ORCID: https://orcid.org/0000-0001-9931-5990)
- Li Yang (ORCID: https://orcid.org/0000-0001-7609-0960)
Institutions
- Baylor College of Medicine (US)
- University of California, Irvine (US)
- Ben Taub Hospital (US)
- Children's Nutrition Research Center at Baylor College of Medicine (US)
Publication Details
- Journal
- Clinical Epigenetics
- Published
- 2025-01-22
- DOI
- https://doi.org/10.1186/s13148-025-01817-z
- Citations
- 9
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 7.25
Funders
- U.S. Department of Agriculture
- National Institutes of Health
- National Cancer Institute