A case report on Pseudo Felty’s syndrome

Pseudo-Felty’s syndrome is a rare disease entity defined by the presence of monoclonal expansion of T lymphocytes with neutropenia in association with rheumatoid arthritis. T-large granular lymphocyte (LGL) leukemia is a lymphoproliferative disease with an indolent behavior. LGL leukemia arises in a setting of sustained immune stimulation, such as autoimmune disorders and chronic viral infections, where there is a clonal expansion of T-LGL (cluster of differentiation [CD]3+/CD8+) cells. In this article, we present the case of a 60-year-old gentleman with Pseudo-Felty’s syndrome who presented with LGL proliferation. He is presently stable on disease modifying anti-rheumatoid drugs including methotrexate.