Apoptosis antagonizing transcription factor expression and its validation as a potential diagnostic and prognostic biomarker in oral squamous cell carcinoma

Elevated expression of AATF in OSCC correlates with adverse clinicopathological features and negatively impacts immune cell infiltration. High AATF levels serve as an independent marker of poor OS and DSS. These findings support AATF as a valuable prognostic biomarker and a potential therapeutic target in OSCC, warranting further investigation.

Authors

Publication Details

Journal
Frontiers in Oncology
Published
2025-01-22
DOI
https://doi.org/10.3389/fonc.2025.1542730
Primary Topic
Cancer-related gene regulation
Type
article
Field-Weighted Citation Impact
0.00

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article

Apoptosis antagonizing transcription factor expression and its validation as a potential diagnostic and prognostic biomarker in oral squamous cell carcinoma

Ainiwaerjiang Abudourousuli, Chengli Da, Zumulaiti Aierken, Hasiyati Mamuti et al.
Frontiers in Oncology
Cancer-related gene regulation
article

Apoptosis antagonizing transcription factor expression and its validation as a potential diagnostic and prognostic biomarker in oral squamous cell carcinoma

Ainiwaerjiang Abudourousuli, Chengli Da, Zumulaiti Aierken, Hasiyati Mamuti, Tuxunayi Yimamu
article en

Abstract

Elevated expression of AATF in OSCC correlates with adverse clinicopathological features and negatively impacts immune cell infiltration. High AATF levels serve as an independent marker of poor OS and DSS. These findings support AATF as a valuable prognostic biomarker and a potential therapeutic target in OSCC, warranting further investigation.

Frontiers in OncologyVol. 15
Natural Science Foundation of Xinjiang
No poverty
Openalex Percentile: Top 99%
Cancer-related gene regulation
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