Knockdown of PDPN in astrocytes reduces hippocampal inflammation in T2DM mice
In summary, this study demonstrates that <i>Pdpn</i> exerts a novel player in T2DM-induced neuroinflammation and cognitive decline. Knocking down <i>Pdpn</i> in astrocytes shows a protective effect in hippocampal inflammation and VaD.
Authors
- Chengming Ni
- Zhensheng Cai
- Yusong Zhao (ORCID: https://orcid.org/0000-0003-0365-7182)
- Hui Liu (ORCID: https://orcid.org/0000-0002-5693-9397)
- Jinbang Wang (ORCID: https://orcid.org/0000-0002-8827-9354)
- Subo Liu
- Xueying Wang (ORCID: https://orcid.org/0000-0001-6445-8887)
- Huan Wang (ORCID: https://orcid.org/0000-0001-9048-2733)
- Xiaohang Wang (ORCID: https://orcid.org/0000-0003-2589-1260)
- Qianqian Wang (ORCID: https://orcid.org/0009-0004-9065-555X)
Institutions
- Zhongda Hospital Southeast University (CN)
- First Hospital of Shijiazhuang (CN)
- Northern Jiangsu People's Hospital (CN)
- Yangzhou University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-01-22
- DOI
- https://doi.org/10.3389/fimmu.2025.1503807
- Citations
- 2
- Primary Topic
- Neurological Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.68