Characterization of Five Natural Anthraquinone Compounds as Potent Inhibitors against CYP1B1: Implications for Cancer Treatment
The present study provided a comprehensive analysis of the inhibitory effects of five natural anthraquinones, namely aloe-emodin, chrysophanol, obtusifolin, aurantio-obtusin and rhein, on CYP1B1 activity, and elucidated the structure-activity relationship. Molecular docking simulations further revealed the specific amino acid residues within the active site of CYP1B1, where these compounds exerted their actions. These findings offer novel insights into investigating the potential antitumor properties of natural anthraquinones.
Authors
- Jian Zhang (ORCID: https://orcid.org/0000-0003-1507-4718)
- Xintong Guan
- Jie Du (ORCID: https://orcid.org/0000-0001-5152-1488)
- Zujia Chen
- C.-Y. Wang (ORCID: https://orcid.org/0000-0001-9513-1246)
- Zhixiang Xu
- Xiaodong Chen (ORCID: https://orcid.org/0000-0001-8583-7384)
- Jingjing Wu (ORCID: https://orcid.org/0000-0002-5046-9996)
Institutions
- Dalian Medical University (CN)
- Second Affiliated Hospital of Dalian Medical University (CN)
Publication Details
- Journal
- Current Drug Metabolism
- Published
- 2025-01-22
- DOI
- https://doi.org/10.2174/0113892002329282250108163208
- Citations
- 1
- Primary Topic
- Phytochemistry and biological activity of medicinal plants
- Type
- article
- Field-Weighted Citation Impact
- 1.75