Better understanding the phenotypic effects of drugs through shared targets in genetic disease networks
This work represents an important advance in our understanding of how drugs cause intended and adverse side effects through their action on disease causing genes and has potential applications for drug development and repositioning.
Authors
- Raquel Yahyaoui (ORCID: https://orcid.org/0000-0001-6789-1563)
- Elena Díaz-Santiago (ORCID: https://orcid.org/0000-0002-6178-8626)
- James R. Perkins (ORCID: https://orcid.org/0000-0003-4108-096X)
- Aurelio A. Moya‐García (ORCID: https://orcid.org/0000-0002-0567-0949)
- Florencio Pazos (ORCID: https://orcid.org/0000-0002-2646-6226)
- Juan A. G. Ranea (ORCID: https://orcid.org/0000-0003-0327-1837)
- Christine Orengo
- José Manuel Pérez-García (ORCID: https://orcid.org/0000-0003-4238-2046)
Institutions
- Instituto de Salud Carlos III (ES)
- Centro Nacional de Biotecnología (ES)
- Hospital Regional Universitario de Málaga (ES)
- Centro de Investigación Biomédica en Red (ES)
- Institute of Structural and Molecular Biology (GB)
- Instituto de Investigación Biomédica de Málaga (ES)
- University College London (GB)
- Universidad de Málaga (ES)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-01-22
- DOI
- https://doi.org/10.3389/fphar.2024.1470931
- Citations
- 1
- Primary Topic
- Computational Drug Discovery Methods
- Type
- article
- Field-Weighted Citation Impact
- 1.50
Funders
- Universidad de Málaga
- Smithsonian Conservation Biology Institute
- Instituto de Salud Carlos III